The Association between Saliva and Serum Vitamin D with Knee Osteoarthritis

Mohammad-Reza  Mirzaii-Dizgah; Mohammad-Hossein  Mirzaii-Dizgah; Iraj  Mirzaii-Dizgah; Roghayeh  Koshkzari

doi:10.18502/jnfs.v8i1.11775

Mohammad-Reza Mirzaii-Dizgah Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Mohammad-Hossein Mirzaii-Dizgah Student Research Committee, School of Dentistry, Aja University of Medical Sciences; Tehran, Iran
Iraj Mirzaii-Dizgah Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran.
Roghayeh Koshkzari Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran1Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jnfs.v8i1.11775

Keywords: Knee osteoarthritis; 25- hydroxycholecalciferol; Saliva

Abstract

Background: The incidence of osteoarthritis (OA) is high in patients suffering from 25-hydroxyvitamin D3 (25(OH)D) deficiency. The goal of this study is to examine the association between saliva and serum 25(OH)D and knee OA. Methods: Serum and saliva 25(OH)D levels of 30 patients with knee OA and 30 matched healthy people in a control group were measured by ELISA. Knee pain was assessed by Western Ontario and McMaster Universities Arthritis Index (WOMAC). Data were analyzed through student’s t-test, Pearson correlation test and receiver operating characteristic (ROC). Results: The mean serum and saliva 25(OH)D levels were lower in knee OA group than the healthy group. WOMAC negatively correlated with serum (r = -0.37; P = 0.02) and with unstimulated (r = -0.30; P = 0.04) saliva 25(OH)D. The unstimulated saliva 25(OH)D cutoff value was 27.8 pg/m1 regarding the diagnosis of knee OA. Conclusion: Serum 25(OH)D levels were positively associated with saliva 25(OH)D, and 25(OH)D level in saliva, as in serum, was low in knee OA.