Resorbable Bone-Fixation Materials: Synthesis, Physical-Chemical and Biological  Properties

Bakhtiniso  Muzaffarova; Sherzod  Eranov; Sanjar  Tillayev

doi:10.18502/ajmb.v17i3.19278

Bakhtiniso Muzaffarova Department of Organic synthesis and Bioorganic chemistry, Samarkand State University named after Sharof Rashidov, Samarkand, Uzbekistan
Sherzod Eranov Department of Traumatology and Orthopedics, Samarkand State Medical University, Samarkand, Uzbekistan
Sanjar Tillayev Department of Organic synthesis and Bioorganic chemistry, Samarkand State University named after Sharof Rashidov, Samarkand, Uzbekistan

DOI: https://doi.org/10.18502/ajmb.v17i3.19278

Keywords: Durapatite, Femur, Hydroxyapatite-polylactide, Lagomorpha, Porosity, Powders

Abstract

Artificial bone materials were synthesized using the "solvent casting method" using polylactide/hydroxyapatite and various organic-inorganic modifiers. The physicochemi-cal properties of the materials were studied using modern methods. IR spectroscopy showed that interactions between polymer macromolecules and hydroxyapatite occurred. When the powder was studied by the X-ray diffraction method, it was found to have an average crystallinity of 50-60%. When the textural properties were examined using SEM analysis, it was found that the introduction of magnesium phosphate into the samples resulted in the formation of porous particles with dimensions of 100-250 µm. This in turn, leads to the improvement of metabolic processes when the samples are introduced into living tissues. When the microhardness was determined by the Vickers method, it was found to be close to the hardness of natural bone, i.e. 27-34 HV. In vitro resorption was also performed in Simulated Body Fluids (SBF). Non-toxicity was observed when cytotoxic properties were studied. When the resorption process was studied in vivo in the upper third of the femur of rabbits, it was found that the ossification process of the samples was satisfactory after 28 days.