Comparison of Ovarian Response in Patients with Cancer and Control Group Treated with In Vitro Fertilisation During 2020-2021

Motahareh  Bitaghsir Fadafan; Marzieh Ghasemi; Maliheh Amirian; Narjes Sargolzai

doi:10.18502/jzms.v5i3.10921

Motahareh Bitaghsir Fadafan Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Marzieh Ghasemi Associate Professor, Pregnancy Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Maliheh Amirian Associate Professor, Pregnancy Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Narjes Sargolzai Associate Professor, Pregnancy Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: https://doi.org/10.18502/jzms.v5i3.10921

Keywords: Ovarian response, In vitro fertilization, Cancer

Abstract

Background: Nowadays, there is a growing tendency to inhibit fertility in women with cancer. This study was designed to evaluate the ovarian response and In vitro fertilisation (IVF) results in infertile women with and without cancer in Zahedan and Mashhad University of Medical Sciences.

Methods: Two groups of patients with (30 patients) and without cancer (60 patients) were studied. Initially, 225 units of FSH were started for patients on days 1 to 3, after the follicles reached 13-14 mm, the steroid antagonist was started, after observing at least two follicles larger than 17 mm, HCG ampoule was injected. Metaphase 2 eggs were microinjected and three days later the embryos were evaluated for quality and frozen. For all patients, a questionnaire was completed by the researcher.

Results: Overall, 90 patients with a mean age of 30.42 ± 5.30 years were studied. Most patients in the case group had breast cancer (15.6%). In this study, age variables, number of eggs with M1 quality, number of eggs with M2 quality, number of punctured eggs, and duration of ovulation stimulation, number of third day embryos, were not significant between the two groups. Variables such as number of eggs with GV quality and mean number of frozen embryos and number of third day embryos A-C quality, and the mean number of third day embryos were statistically significant between the two groups.

Conclusion: According to the results of this study, in many cases, no statistically significant difference was observed between the control and case groups, and ovarian stimulation could provide a good chance for future pregnancy and women with cancer to produce similar eggs and embryos produced by women without cancer.