Dual-Modality Therapy: Synergistic Enhancement of Radio-Hyperthermia by Gold-Gold Sulfide Nanoparticles in MCF-7 Cells

Mahdi  Sadat-Darbandi; Amirhossein  Fathabadi; Shabnam  Oloomi; Ameneh  Sazgarnia

doi:10.18502/ajmb.v17i4.20076

Mahdi Sadat-Darbandi Department of Medical Physics, Reza Radiotherapy and Oncology Center, Mashhad, Iran
Amirhossein Fathabadi Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Shabnam Oloomi Department of Radiology Technology, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
Ameneh Sazgarnia Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: https://doi.org/10.18502/ajmb.v17i4.20076

Keywords: Combined modality therapy, Hyperthermia, Induced, Metal nanoparticles, MCF-7 cells, Radiotherapy

Abstract

Background: This study examines the synergistic impact of Gold-Gold Sulfide (GGS) nanoparticles combined with hyperthermia and radiotherapy on MCF-7 cancer cells. GGS nanoparticles, with strong near-infrared absorption and photothermal properties, enhance cellular sensitivity to radiotherapy.

Methods: MCF-7 cells were treated with varying GGS concentrations and exposed to radiation doses of 50, 100, and 200 cGy, alongside laser irradiation for 10, 40, and 80 s. The IC₅₀ for GGS nanoparticles was approximately 350 µM.

Results: Results revealed a significant reduction in cell viability with the combined GGS and laser exposure (p<0.001), demonstrating a synergistic effect in a dose-dependent manner. Further enhancement in cell viability reduction was observed when GGS nanoparticles were combined with both hyperthermia and radiotherapy (p<0.01).

Conclusion: These findings suggest that GGS nanoparticles offer greater efficacy and reduced toxicity compared to gold nanoparticles, highlighting their potential for improving cancer therapy outcomes through combined hyperthermic and radiotherapeutic approaches.