Exploring the Potential of In vitro Maturation (IVM) of Oocytes: Indications,  Applications, and Treatment Protocols

Hossein  Torkashvand; Ronak  Shabani; Iraj  Amiri; Roya  Darakhshan; Behnam Maleki; Mohammad Reza  Doostabadi; Mehdi  Mehdizadeh

doi:10.18502/ajmb.v16i3.15741

Hossein Torkashvand Department of Anatomical Science, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Ronak Shabani Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran
Iraj Amiri Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran
Roya Darakhshan Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran
Behnam Maleki Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran
Mohammad Reza Doostabadi Department of Anatomy, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Mehdi Mehdizadeh Reproductive Sciences and Technology Research Center, Department of Anatomy, Iran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/ajmb.v16i3.15741

Keywords: Clinical protocol, Fertility preservation, In vitro maturation oocyte (IVM)

Abstract

Background: This review addresses the current understanding of In Vitro Maturation (IVM) treatment, including indications and effective treatment protocols influencing oocyte developmental competence.

Methods: A comprehensive literature search was performed to gather relevant studies, clinical trials, and reviews related to IVM. Databases such as PubMed, MEDLINE, and pertinent medical journals were searched. The selected literature was analyzed and synthesized to offer a comprehensive overview.

Results: IVM has emerged as a promising technique for inducing maturation in immature oocytes across various developmental stages. Its applications extend to areas utilizing In Vitro Fertilization (IVF), gaining traction as a treatment option for Polycystic Ovary Syndrome (PCOS) and fertility preservation in cancer patients. Recent advancements have led to improved global pregnancy rates, resulting in successful births. IVM also holds potential in reducing risks associated with conventional IVF, including ovarian hyperstimulation syndrome and multiple pregnancies. Despite these advantages, IVM adoption in clinical practice remains limited. Ongoing research aims to refine therapeutic protocols and expand clinical indications.

Conclusion: IVM holds promise in assisted reproductive technology, spanning applications from cancer patient fertility preservation to addressing PCOS. Enhanced pregnancy rates highlight efficacy, while risk reduction compared to IVF underscores its importance. Further research is needed for optimal use across patient groups, emphasizing protocol refinement and expanded applications.