Formulation, Characterization, and Evaluation of Wound Healing Potency of  a Novel Mattan tailam Nanogel Based on a Famous Traditional Siddha Formula

Meenachisundaram  Sakthiganapathi; Gnanakumar Prakash  Yoganandam; Venkatachalam  Gopal

doi:10.18502/ajmb.v15i1.11423

Meenachisundaram Sakthiganapathi Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, A Government of Puducherry Institution, Gorimedu, Puducherry 605 006. India
Gnanakumar Prakash Yoganandam Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, A Government of Puducherry Institution, Gorimedu, Puducherry 605 006. India
Venkatachalam Gopal Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, A Government of Puducherry Institution, Gorimedu, Puducherry 605 006. India

DOI: https://doi.org/10.18502/ajmb.v15i1.11423

Keywords: Collagen, Hydroxyproline, Nanogels, Rats, Tensile strength, Wound healing

Abstract

Background: The Mattan tailam mixture has been extensively used to heal ulcerous wounds in traditional Siddha practice. The present study aimed to synthesize a Mattan tailam nanogel and evaluate the enhancement of wound healing potential in an experimental wound model.

Methods: Mattan tailam nanogel was synthesized using the high-energy milling approach, and characterization of nanogel and potency of wound healing was investigated. The novelty of this study was the nanogel preparation of Mattan tailam.

Results: As expected, a synthesized novel nanogel of Mattan tailam has a distinct, prominent peak with a spherical form, is negatively charged and has an average particle size of 20–30 nm. Mattan tailam nanogel treated rats showed a remarkable reduction (p<0.001) in the wound area. On the 16^th day, 10% Mattan tailam nanogel treatment resulted in a higher percentage of wound contraction. The 10% Mattan tailam nanogel group exhibited a faster epithelialization time (14.33 days) and a greater hydroxyproline concentration than the others. The topical application of 10% Mattan tailam nanogel increased tensile strength, signifying a better therapeutic indication.

Conclusion: The present findings prove that polyherbal Mattan tailam nanogel formulation significantly improves collagen production, wound contraction, and tensile strength.