The Role of Tranexamic Acid in Reducing Blood Loss Following Total Joint Arthroplasty: A Review Article

Ehsan Fallah; Alireza Moharrami; Amir Hossein  Ahmadi Nouri; Mir Mansour  Moazen Jamshidi; Amir Reza Mafi; Seyed Mohammad Javad Mortazavi

doi:10.18502/jost.v8i1.9038

Ehsan Fallah Knee Surgery Fellowship, Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Alireza Moharrami Resident, Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Amir Hossein Ahmadi Nouri General Practitioner, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Mir Mansour Moazen Jamshidi Hip Surgery Fellowship, Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Amir Reza Mafi Hip Surgery Fellowship, Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Seyed Mohammad Javad Mortazavi Professor, Joint Reconstruction Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/jost.v8i1.9038

Keywords: Tranexamic Acid; Postoperative Hemorrhage; Arthroplasty; Knee; Hip

Abstract

Total Joint Arthroplasty (TJA) is a major surgery performed for patients who suffer from severe joint destruction. It is so important to reduce the blood loss in the TJA surgery to decrease the infection rate, falling, and other complications following the surgery. Many methods could reduce blood loss, such as mechanical methods and chemical methods. Tranexamic acid (TXA) is a chemical method to reduce blood loss in surgery. There are numerous methods of administration of TXA in the literature, such as intravenous (IV), intra-articular, and combination of intra-articular and -venous methods. In the present review article, we review the studies that compared the efficacy of each method of the TXA administration.