Assessment of Physical and Mechanical Parameters of the Left Ventricle by Speckle Tracking Technique for Prediction Coronary Artery Disease Patients

Zeinab Alsadat Ahmadi; Manijhe  Mokhtari Dizaji; Anita  Sadeghpour; Hamideh Khesali; Ata  Firouzi

doi:10.18502/fbt.v9i3.9647

Zeinab Alsadat Ahmadi Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Manijhe Mokhtari Dizaji Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Anita Sadeghpour Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Hamideh Khesali Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Ata Firouzi Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/fbt.v9i3.9647

Keywords: Strain; Strain Rate; Speckle Tracking Echocardiography.

Abstract

Purpose: The goal of the study was to identify earlier pathology of the Left Ventricle (LV) using Speckle Tracking Echocardiography (STE) without angiography results for detecting Coronary Artery Disease (CAD) patients who have need invasive coronary reperfusion.

Materials and Methods: A total of seventy-five referral patients to angiography (mean age 57±9 years) with chest pain, underwent Two-Dimensional Echocardiography (2D-ECG). Conventional echocardiographic parameters were calculated for the assessment of LV function. End systole and early diastole longitudinal strain, strain rate, and velocity with 2D-STE were estimated to evaluate myocardial function. Discriminated analysis was performed to detect CAD patients from the healthy group.

Results: According to the angiography results, patients were divided into CAD group (n=55) and healthy group (n=20). There was a significant decrease in longitudinal strain, strain rate, and velocity in patients with CAD compared to the healthy group (systolic longitudinal strain for CAD group -15.9±2.2% vs. -19.6±2.2% for healthy group and early diastolic longitudinal strain for CAD patients -9.5±1.2% vs. -12.0±1.3% for the healthy group) (P-value<0.05). Discriminate analysis of end-systolic and early diastolic longitudinal strain with 81.8% and 89.1% indicated the highest sensitivity, respectively.

Conclusions: End systolic and early diastolic longitudinal strain parameters derived with the STE method are superior predictors for detecting CAD patients referred to angiography for revascularization.