Classification of the Children with ADHD and Healthy Children Based on the Directed Phase Transfer Entropy of EEG Signals

Ali   Ekhlasi; Ali  Motie Nasrabadi; Mohammadreza   Mohammadi

doi:10.18502/fbt.v8i2.6515

Ali Ekhlasi Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Ali Motie Nasrabadi Department of Biomedical Engineering, Faculty of Engineering, Shahed University, Tehran, Iran
Mohammadreza Mohammadi Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/fbt.v8i2.6515

Keywords: Attention Deficit Hyperactivity Disorder; Electroencephalography; Phase Transfer Entropy; Effective Connectivity; Classification.

Abstract

Purpose: The present study was conducted to investigate and classify two groups of healthy children and children with Attention Deficit Hyperactivity Disorder (ADHD) by Effective Connectivity (EC) measure. Since early detection of ADHD can make the treatment process more effective, it is important to diagnose it using new methods.

Materials and Methods: For this purpose, Effective Connectivity Matrices (ECMs) were constructed based on Electroencephalography (EEG) signals of 61 children with ADHD and 60 healthy children of the same age. ECMs of each individual were obtained by the directed Phase Transfer Entropy (dPTE) between each pair of electrodes. ECMs were calculated in five frequency bands including, delta, theta, alpha, beta, and gamma. Based on ECM, an Effective Connectivity Vector (ECV) was constructed as a feature vector for the classification process. Furthermore, ECV of different frequency bands was pooled in one global ECV (gECV). Multilayer Artificial Neural Network (ANN) was used in the steps of classification and feature selection by the Genetic Algorithm (GA).

Results: The highest classification accuracy with the selected features of ECV was related to theta frequency band with 89.7%. After that, the delta frequency band had the highest accuracy with 89.2%. The results of ANN classification and GA on the gECV reported 89.1% of accuracy.

Conclusion: Our findings show that the dPTE measure, which determines effective connectivity between the brain regions, can be used to classify between ADHD and healthy groups. The results of the classification have improved compared to some studies that used the functional connectivity measures.