The Investigation of Conductivity of Magnetic Nanoparticles in the Vascular Network by DCC Method and the Effect of Forces on the Efficiency of Targeted Magnetic Drug Delivery

Seyed Erfan  Saadatmand; Seyede Mahsa  Kavousi; Nader  Riyahi Alam

doi:10.18502/fbt.v8i1.5855

Seyed Erfan Saadatmand Department of Physics and Medical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Seyede Mahsa Kavousi Department of Physics and Medical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Nader Riyahi Alam Department of Physics and Medical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/fbt.v8i1.5855

Keywords: Targeted Drug Delivery; Simulation; Magnetic Nanoparticles; Blood Vessel; Comsol Multiphysics.

Abstract

Purpose: Targeted magnetic drug delivery is one of the methods of cancer treatment. In this method, magnetic factors are conducted inside the body by a variable external magnetic field and deliver the drug agents to the tumor area. The present study aimed to investigate the performance of the drug magnetic conduction by using Differential Current Coil (DCC) and the effect of gravity force on it.

Materials and Methods: In mathematical modeling, magnetic, hydrodynamic and gravity forces were assumed to affect the movement of magnetic nanoparticles inside the vessels. Helmholtz coils with a circular cross-section and different currents were simulated in the software environment. The trajectory of nanoparticles within the static fluid, Y-shape channel and multi-branch vascular network was calculated. The relations between the magnetic force applied on the magnetic nanoparticles and the parameters of coil flow, radius and relative permeability of the nanoparticles were investigated.

Results: The magnetic flux generated in the coils was calculated and the particles moved in the direction of the magnetic gradient. The diagram of magnetophoresis force changes with the physical parameters was calculated. Particle trajectory and correct exit rate were obtained in simulated vessels. The output changes in the state of with-the-effect and without-the-effect of gravity were about 1.5 to 3%. The output changes of the correct and incorrect branches were calculated by changing the angle of the branches.

Conclusion: From the approximate reduction of 2% of the correct output, it can be concluded that the effect of gravity on the conductivity of the system can be neglected. Besides, it seems that as the injection point is closer to the conduction point, the amount of the correct output will increase more.