Finite Element Analysis of Cell Killing Probability in Electroporation with Single Bipolar Electrode

Abstract

Purpose: In the electroporation we can use different electrode types such as needle and plate electrode with different arrangements. One of the new electrode types is single bipolar electrode that the anode and cathode components are in the same needle for decreasing the invasiveness of electroporation procedure.

Materials and Methods: For treatment planning purposes we can use different cell killing probability models such as Peleg-Fermi model. The aim of this study is to investigate the impact of geometric electrode parameters such as conductive pole length, insulated pole length and pulse voltage in bipolar electrode on the cell killing probability distribution in electroporation by COMSOL Multiphysics.

Results: The target tissue volume with cell killing probability of >80% was increased with conductive pole length, and voltage and decreased with insulated pole length.

Conclusion: This paper has highlighted the importance of conductive and insulated pole length and voltage in bipolar electrode on the cell killing probability distribution and electroporated volume in the EP.