Evaluation of Conventional Treatment Planning Techniques for Radiotherapy of Gastroesophageal Junction Cancer: A Dosimetric Comparison between Male and Female Patients

Mohamad  Pursamimi; Mahdi  Ghorbani; Mehdi  Khosravi; Ghazal  Mehri-Kakavand; Wrya  Parwaie; Seyed Mohammad  Hosseini; Ali Mohammad  Sharifi; Meysam  Tavakoli

doi:10.18502/fbt.v12i2.18273

Mohamad Pursamimi Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mahdi Ghorbani Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mehdi Khosravi Vali-e-Asr Radiotherapy and Oncology Center, Vali-e-Asr Hospital, Qom, Iran
Ghazal Mehri-Kakavand Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Wrya Parwaie Department of Medical Physics, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran
Seyed Mohammad Hosseini Department of Medical Physics and Medical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Ali Mohammad Sharifi Clinical Research Development Center, Shahid Modarres Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Meysam Tavakoli Department of Radiation Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

DOI: https://doi.org/10.18502/fbt.v12i2.18273

Keywords: Radiotherapy; Gastroesophageal Junction Cancer; Dosimetric Parameters; Treatment Planning.

Abstract

Purpose: Gastro-Esophageal (GE) junction cancer has been increasingly prevalent worldwide. This study aims to compare dosimetric and radiobiological parameters for target areas and Organs At Risk (OARs) in men and women patients diagnosed with GE junction cancer.

Materials and Methods: Here, thirty patients who underwent radiotherapy using a 6-MV photon beam from a linear accelerator (Shinva Medical, Shandong, China) were selected. Dosimetric and radiobiological parameters within the Planning Target Volume (PTV) and OARs were compared among all patients using a paired-sample t-test. Additionally, a comparative analysis of Field-In-Field (FIF), three-Field (3F), and four-Field Box (4FB) planning techniques was conducted for both men and women patients.

Results: In terms of dose distribution in the PTV, a significant difference exists between male and female patients regarding TCP and Monitor Unit (MU). Furthermore, in terms of dose distribution in OARs, there is also a significant difference between males and females in terms of NTCP for the right lung and V20 Gy for the right lung.

Conclusion: In general, most dosimetric parameters exhibited similarities between male and female patients. However, notable differences surfaced in TCP, MU, and specific parameters, including NTCP and V20Gy for the right lung. Hence, it is prudent to emphasize meticulous attention in treatment planning for GE junction cancer, considering the anatomical variations between males and females.