An Unsuspecting Recurrent Cryptogenic Stroke: A Case Report

Mahavishnu Sahadevan; Kushanthini Sivaloganathan; Tung Yu Feng

doi:10.18502/crcp.v6i6.9165

Mahavishnu Sahadevan Department of Neurology, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia
Kushanthini Sivaloganathan Department of Emergency Medicine, Seremban General Hospital, Seremban, Malaysia.
Tung Yu Feng Department of Internal Medicine, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia.

DOI: https://doi.org/10.18502/crcp.v6i6.9165

Keywords: CADASIL; Young stroke, NOTCH 3; Migraine

Abstract

Cerebral Autosomal Dominant Arteriopathy with Sub-Cortical Infarcts and Leukoencephalopathy (CADASIL) is a rare autosomal genetic disorder that affects the brain’s small vessels. It is recognized among the leading causes of stroke in the young.

This is a case report of a 35-year-old female with underlying migraine with auras who presented with recurrent cryptogenic strokes. She presented no vascular risk factors or any family history of neurological disease. An investigation into her presentation leads us to a diagnosis of CADASIL following typical subcortical and deep white matter changes seen on her Magnetic Resonance Imaging (MRI).