A Meta-Analysis for Frequency of Miscarriage in Pregnant Women  with COVID-19

Negin Hajialiakbari; David A. Schwartz; Atiyeh Javaheri; Mojgan  Karimi-Zarchi; Mohammad  Golshan-Tafti; Seyed Alireza Dastgheib; Reza Bahrami; Leila Zanbagh; Hossein Neamatzadeh

doi:10.18502/wjpn.v4i2.8648

Negin Hajialiakbari Department of Obstetrics and Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran
David A. Schwartz Department of Pathology, Medical College of Georgia, Augusta, GA, USA
Atiyeh Javaheri Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mojgan Karimi-Zarchi Endometriosis Research Center, Iran University of Medical Sciences, Firoozgar Hospital, Tehran, Iran
Mohammad Golshan-Tafti Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
Seyed Alireza Dastgheib Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Reza Bahrami Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Leila Zanbagh Department of Obstetrics and Gynecology, Yazd Branch, Islamic Azad University, Yazd, Iran
Hossein Neamatzadeh Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/wjpn.v4i2.8648

Keywords: SARS-COV-2; COVID-19; Pregnancy; Abortion; Miscarriage; Frequency

Abstract

Background: Most pregnant women with COVID-19 develop less severe form of the disease, with few cases of severe maternal morbidity and mortality, or perinatal deaths. This meta-analysis was conducted to evaluate the frequency of miscarriage in pregnant women affected by the SARS-COV-2 infection.

Methods: A comprehensive search was performed in online databases to identify all relevant studies published up to 5th March 2021. Case-control studies and case series reported the frequency of miscarriage in pregnant women with COVID-19 was selected.

Results: A total of 22 studies with 8591 infected pregnant women and 141 abortions were selected. The frequency of miscarriage was 3.9% (95% CI 0.023-0.063) in infected pregnant women with COVID-19. It had the highest frequency in Asian (6.3%) followed by European (2.9%), West-Asian (2.5%) and Caucasian (2.3%) infected pregnant women. Moreover, stratified analysis by country showed that the frequency of miscarriage is the highest in Chinese (11.3%) followed by Italy (11.2%), India (2.7%), Turkey (2.2%), USA (1.2%) and France (0.9%) infected pregnant women.

Conclusion: Our pooled data revealed that the frequencies of miscarriage in pregnant women with SARS-COV-2 infection were 3.9%.