Association between FVL G1691A, MTHFR C677T and A1298C  Polymorphisms with Risk for Retinopathy of PrematurityAssociation between FVL G1691A, MTHFR C677T and A1298C  Polymorphisms with Risk for Retinopathy of Prematurity

Hamideh  Shajari; Mohammadamin Ghadyani; Seyed Hamed  Hosseini-Jangjou; Reza Bahrami; Seyed Alireza Dastgheib; Hossein Neamatzadeh

doi:10.18502/wjpn.v4i1.7540

Hamideh Shajari Department of Pediatrics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammadamin Ghadyani Department of Advanced Medical Sciences and Technologies, Islamic Azad University, Science and Research Branch, Tehran, Iran
Seyed Hamed Hosseini-Jangjou Department of Pediatrics, Iranshahr University of Medical Sciences, Iranshahr, Iran
Reza Bahrami Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed Alireza Dastgheib Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Neamatzadeh Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/wjpn.v4i1.7540

Keywords: Retinopathy of Prematurity; Neonate; Factor V Leiden; MTHFR Gene

Abstract

Background: Retinopathy of prematurity (ROP) is an important cause of preventable blindness in children. The aim of this study was to examine the association of the polymorphisms at Factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene with risk of ROP.

Methods: A total of 106 neonates with ROP and 110 healthy neonates were enrolled. The FVL G1691A and MTHFR C677T and A1298C polymorphisms were genotyped by PCR-RFLP assay.

Results: There was a significant association between FVL G1691A polymorphism and an increased risk of ROP. However, the MTHFR C677T and A1298C polymorphisms were not associated with risk of ROP.

Conclusion: FVL G1691A polymorphism may be risk factor for development of ROP in neonates. However, there was no significant association between MTHFR C677T and A1298C polymorphisms and risk of ROP. However, it is critical that larger and well-designed studies in different ethnicities are needed to confirm our conclusions.