Evaluation of the effect of inhaled salbutamol in the treatment of neonates with a diagnosis of TTN

Hasan  Vahedi-Zarch; Mohamad Hosein  Lookzadeh; Mahmood  Noorishadkam; Seyed Reza  Mirjalili; Mohammadreza Gholami Banadkoki; Farimah  Shamsi

doi:10.18502/wjpn.v7i2.20447

Hasan Vahedi-Zarch Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohamad Hosein Lookzadeh Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mahmood Noorishadkam Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Reza Mirjalili Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammadreza Gholami Banadkoki Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Farimah Shamsi Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/wjpn.v7i2.20447

Keywords: Transient tachypnea, Respiratory distress, Salbutamol, Oxygen therapy

Abstract

Introduction: Transient tachypnea of the newborn (TTN) is the most common cause of transient respiratory distress in the newborn, which occurs as a result of insufficient or delayed absorption of fetal alveolar fluid immediately after birth. Considering that few studies have been conducted in the field of evaluating the effectiveness of inhaled salbutamol in TTN patients, therefore, the present study aimed to determine the effects of inhaled salbutamol in the treatment of TTN, as well as investigate the possible side effects of treatment with it.

Methods: This study was a double-blind randomized clinical trial in which 100 infants with a minimum gestational age of 35 weeks, with a diagnosis of TTN, participated. These infants were randomly divided into two groups receiving inhaled salbutamol and the control group, then in the first 6 hours of birth, the group receiving the therapeutic intervention received a dose of salbutamol, and the control one received a dose of normal saline both by nebulization. And then the effectiveness of salbutamol in changing the clinical and laboratory indicators of infants with TTN and the possible side effects of this treatment method was examined.

Results: It was seen that in the group receiving inhaled salbutamol, the TTN score decreased significantly in the first and sixth hours after receiving the intervention compared to the control group. Also, the results showed that the time required to start oral feeding was longer in the group receiving salbutamol than in the control group. This is while no significant difference was observed between the two groups in terms of indicators such as length of hospitalization, duration of need for oxygen therapy, and other clinical indicators of infants.

Conclusion: Considering that infants with TTN treated with inhaled salbutamol were not significantly different from the control group in terms of treatment complications and considering the other results mentioned, it can be said that the use of inhaled salbutamol can be an effective and less harmful option in the treatment of infants suffering from TTN.