Evaluation of the Effect of Inhaled Salbutamol in the Treatment of   Neonates with a Diagnosis of TTN

Hasan  Vahedi-Zarch; Mohamad Hosein  Lookzadeh; Mahmood  Noorishadkam; Seyed Reza  Mirjalili; Mohammadreza Gholami Banadkoki; Farimah  Shamsi

doi:10.18502/wjpn.v7i2.20447

Hasan Vahedi-Zarch Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohamad Hosein Lookzadeh Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mahmood Noorishadkam Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Reza Mirjalili Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammadreza Gholami Banadkoki Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Farimah Shamsi Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/wjpn.v7i2.20447

Keywords: Transient tachypnea, Respiratory distress, Salbutamol, Oxygen therapy

Abstract

Background: Transient tachypnea of the newborn (TTN), the most common cause of transient respiratory distress in neonates, occurs due to insufficient or delayed absorption of fetal alveolar fluid immediately after birth. Given the limited number of studies evaluating the effectiveness of inhaled salbutamol in TTN patients, this study aimed to assess the therapeutic effects of inhaled salbutamol and to investigate its potential side effects.

Methods: This study was a double-blind randomized clinical trial involving 100 infants with a gestational age of at least 35 weeks, who were diagnosed with TTN. The infants were randomly assigned into two groups. Within the first 6 hours after birth, the intervention group received inhaled salbutamol, while the control group received normal saline, both administered nebulization. The effectiveness of salbutamol on clinical and laboratory parameters, as well as its potential side effects, was examined in infants with TTN.

Results: The TTN score decreased significantly in the salbutamol group at 1 and 6 hours after the intervention compared with the control group. Additionally, the time required to initiate oral feeding was longer in the group receiving salbutamol. However, regarding the length of hospitalization, duration of oxygen therapy, and other clinical parameters, no significant difference was observed between the two groups.

Conclusion: Since no significant differences were observed in major clinical outcomes between the groups, inhaled salbutamol may be considered a safe and potentially effective therapeutic option for infants with TTN