Enlightening the Correlation of Polymorphisms at FTO, LEP and LEPR Genes with Gestational Diabetes Mellitus Risk: a Meta-analysis

Mohammad  Golshan-Tafti; Hossein Aarafi; Nazanin Hajizadeh; Seyed Alireza Dastgheib; Reza Bahrami; Mojgan Karimi-Zarchi; Maryam Aghasipour; Hajar Abbasi; Sepideh Azizi; Amirmasoud Shiri; Leila Azod; Hossein Neamatzadeh

doi:10.18502/wjpn.v6i1.14250

Mohammad Golshan-Tafti Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
Hossein Aarafi Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
Nazanin Hajizadeh Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Seyed Alireza Dastgheib Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Reza Bahrami Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mojgan Karimi-Zarchi Firoozgar Clinical Research Development Center (FCRDC), Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Maryam Aghasipour Department of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, USA
Hajar Abbasi Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sepideh Azizi Akbarabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran
Amirmasoud Shiri Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Leila Azod Cellular and Molecular Biology Research Center, School of Medicine, Shahid Sadoughi Yazd University of Medical Sciences, Yazd, Iran
Hossein Neamatzadeh Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/wjpn.v6i1.14250

Keywords: Gestational Diabetes Mellitus; FTO; Leptin; Obesity; Metabolic; Polymorphism

Abstract

Background: The adverse outcomes correlated with GDM for both the mother and the offspring are diverse. The link between polymorphisms at fat mass and obesity‐correlated protein (FTO), leptin (LEP), and leptin receptor (LEPR) genes and GDM is ambiguous. In this meta-analysis, we sought to investigate the correlation of FTO, LEP, and LEPR polymorphisms with GDM risk.

Methods: We performed an online search on PubMed, Web of Science, and Google Scholar databases to identify all relevant research.

Results: A total of 18 case-control studies including seven research with 893 cases and 2875 controls on FTO rs9939609, four research with 1345 cases and 1116 controls on FTO rs8050136, two research with 207 cases and 205 controls on FTO rs1421085, three studies with 529 cases and 581 controls on LEP rs7799039, and two research with 480 cases and 477 controls on LPER rs1137101 met our criteria. Combined data illustrated that the FTO rs9939609 and rs8050136 were correlated with a substantial risk of GDM in the overall population, but not FTO rs1421085. Furthermore, LEP rs2167270 and rs7799039 polymorphisms were not correlated with GDM risk. Sorted analyses illustrated that the FTO rs9939609 polymorphism was correlated with GDM in Caucasian women.

Conclusion: This meta-analysis results illustrated that the FTO rs9939609 and rs8050136 were correlated with a substantial risk of GDM, but not FTO rs1421085, LEP rs7799039, and LPER rs1137101. Larger and more rigorous studies among different ethnicities are needed to further evaluate the correlations with GDM.