Genetic Association between ITPKC rs28493229 Polymorphism and Susceptibility to Kawasaki Disease: A Meta-Analysis

Seyed Alireza Dastgheib; Fatemeh Asadian; Azadeh Tahooni; Reza Bahrami; Mahmood Noorishadkam; Seyed Reza Mirjalili; Hossein Neamatzadeh

doi:10.18502/wjpn.v5i2.11995

Seyed Alireza Dastgheib Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Asadian Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
Azadeh Tahooni Department of Cardiology, Firoozgar Hospital Research Center, Iran University of Medical Sciences, Tehran, Iran
Reza Bahrami Neonatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Mahmood Noorishadkam Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Seyed Reza Mirjalili Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hossein Neamatzadeh Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/wjpn.v5i2.11995

Keywords: Kawasaki Disease; ITPKC Gene; Vasculitis; Polymorphism; Association

Abstract

Background: Studies investigating the association between ITPKC rs28493229 polymorphisms and Kawasaki disease (KD) risk found inconsistent data. Thus, we performed this meta-analysis to combine and analyze the available studies to get a precise estimation of the association.

Methods: Relevant studies identified in the PubMed, Web of Science, Scopus, and CNKI databases were used to perform a meta-analysis. Pooled odds ratios (OR) with a 95% confidence interval (95% CI) were calculated under fixed- and random-effects models to appraise the association.

Results: A total of eight case-control studies with 2,721 KD cases and 5,307 controls were selected. The results showed a statistically significant association between ITPKC rs28493229 polymorphism and an increased risk of KD under all five genetic models, i.e., allele (C vs. G: OR = 1.434, 95% CI 1.209-1.700, P ≤ 0.001), homozygote (CC vs. GG: OR = 2.085, 95% CI 1.423-3.055, P ≤ 0.001), heterozygote (CG vs. GG: OR = 1.530, 95% CI 1.359-1.722, P ≤ 0.001), dominant (CC+CG vs. GG: OR = 1.490, 95% CI 1.229-1.806, P ≤ 0.001), and recessive (CC vs. CG + GG: OR = 1.799, 95% CI 1.231-2.629, P = 0.002) in the overall population. When stratified by country, there was a significant association among Taiwanese.

Conclusion: Our meta-analysis results supported that the ITPKC rs28493229 polymorphism is strongly associated with susceptibility to KD.