Effectiveness of Vitamin C Supplementation on Bone Mineral Density and Peripheral Arterial Quality

Authors

  • Narisa Rueangsri Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Natthakan Kanchana Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Preechayapa Silarod Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Bongkochnuch Ruangpum Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Kannatcha Phengkrajang Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Onpreeya Chumjit Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Punyada Seesod Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Patcharin Janhom Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand;
  • Paphatsara Uaongnarat Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand
  • Chayuttapong Benjaprom Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand
  • Woranitta Petsiri Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand
  • Natbodin Jueajaiamnart Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand
  • Niratchaporn Thanopajai Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Burapha University, Chonburi, Thailand
  • Lukkamol Prapkree Sodexo at the University of Kansas Health System, Olathe, KS, United States.

DOI:

https://doi.org/10.18502/jnfs.v11i3.22164

Keywords:

Ankle brachial index; Bone mineral density; Peripheral arterial quality; Vitamin C; DEXA

Abstract

Background: Vitamin C is an essential nutrient vital for optimal human health. Previous findings have indicated the potential benefits of vitamin C on bone mineral density (BMD) and peripheral arterial quality through various mechanical pathways. However, the effectiveness of vitamin C supplementation on BMD and peripheral arterial quality remains controversial. Methods: A total of 60 healthy participants were recruited and randomly allocated into control (n=30) and intervention (n=30) groups. Background data such as body composition were collected from all participants using BODPOD. Additionally, BMD measurements of wrist and ankle were obtained using an Osteo checker device, and peripheral arterial quality was assessed using the Ankle Brachial Index (ABI) device at baseline. The intervention group received daily vitamin C supplementation of 100 mg per 1 tablet for 12 weeks, whereas the control group maintained their routine dietary habits. All parameters were reassessed at week 12 (endpoint). Results: At endpoint, ankle BMD values in the intervention group were significantly higher than in the control group (P<0.05). Moreover, the intervention group demonstrated significantly higher peripheral arterial quality in both right and left brachial ABI and right and significantly lower left ankle Arterial Stiffness Index (ASI) compared to the control group at endpoint (P<0.05). Dietary habits, including energy and calcium intake, showed no significant differences between groups. Conclusions: Daily vitamin C supplementation of 100 mg appeared to be potentially effective for improving BMD and ABI values among participants in this study. However, further study is needed with larger participant groups and longer duration to confirm these findings.

Published

2026-08-02

Issue

Volume (11) issue (3)

Section

Articles