The Association between Dietary Polyphenols Intake and Risk of Liver Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Arezoo sadat  Emrani; Fatemeh  Mirjalili; Hooman Yekrang  Safakar; Bita  Forootani; Amin  Salehi-abargouei

doi:10.18502/jnfs.v10i2.18544

Arezoo sadat Emrani Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Fatemeh Mirjalili Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Hooman Yekrang Safakar Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Bita Forootani Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Amin Salehi-abargouei Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

DOI: https://doi.org/10.18502/jnfs.v10i2.18544

Keywords: Polyphenols; Isoflavones; Liver neoplasms; Hepatocellular cancer

Abstract

Background: The current data on the association between dietary polyphenols intake and liver cancer are not conclusive. Therefore, we aimed to perform a systematic review and meta-analysis of observational studies on the association between dietary polyphenol intake and liver cancer. Methods: A systematic search of online databases, including PubMed/MEDLINE, Scopus, and Web of Science, was conducted until August 2024. Observational studies that investigated the association between dietary intake of polyphenols and the risk of liver cancer were included. The overall effects were assessed using the random effects model. Results: Totally, four studies were eligible to be included in the systematic review, and for meta-analysis, 3 studies with 4 effect sizes were included. The overall association between dietary intake of isoflavones and the risk of liver cancer was not significant (P=0.35, 95% CI: 0.58-1.21). Conclusion: No significant association was found between dietary polyphenols intake and liver cancer risk. Further observational studies are suggested to confirm these findings