Onset of Mania by Vitamin B12 Injection in a 52-Year Old Patient with Refractory and Resistant Depression

Valentina Artoonian; Vajiheh  Aghamollaii; Azadeh Nadjarzadeh; Reza Bidaki

doi:10.18502/jnfs.v8i2.12589

Valentina Artoonian Department of Psychiatry, Fellowship in Psychotherapy. Tehran University of Medical Sciences, Tehran, Iran
Vajiheh Aghamollaii Department of Neurology, Tehran University of Medical Sciences, Tehran, Iran
Azadeh Nadjarzadeh Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Reza Bidaki Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd , Iran

DOI: https://doi.org/10.18502/jnfs.v8i2.12589

Keywords: Refractory depression; Bipolar disorder; Vitamin B12 deficiency

Abstract

Vitamin B₁₂ affects and modify the function of multiple organ systems. Its deficiency may cause psychiatric symptoms in addition to hematologic, gastrointestinal, and neurologic manifestations. The present case study aims to report a patient with vitamin B₁₂ deficiency who coexisted with resistant and persistent depression, and experienced mania phase after the replacement of vitamin B₁₂. For a patient with refractory and resistant depression and evidence or a risk factor for vitamin B₁₂ deficiency, it is required to check plasma levels and monitor psychiatric symptoms during vitamin B₁₂ supplementation. There are some manifestations of B₁₂ deficiency including bipolar disorder, mood lability, irritability, and psychosis due to deficiency but we didn’t find case report about induce of psychiatric presentation follow correction of vitamin B₁₂ deficiency .