Biochemical interplay between gut microbiota, nutritional modulators, and mycotoxin detoxification, a triadic framework for foodborne toxicity mitigation: a review

Abstract

Mycotoxins secondary metabolites from fungi such as Aspergillus, Fusarium, and Penicillium arewidespread food contaminants that pose health risks, particularly in undernourished populations.Nutritional deficiencies and gut microbiota imbalances further compound their toxicity. This reviewexplores the biochemical interplay among gut microbiota, dietary nutrients, and mycotoxindetoxification. A systematic review was conducted following PRISMA 2020 guidelines. Peer-reviewed studies published from January 2020 to March 2025 were retrieved from PubMed, Scopus,and Web of Science. Studies involving mycotoxins, gut microbiota, and nutritional modulationwere included. Risk of bias was assessed using RoB 2 and PRISMA-ScR tools. Host phase I and IIenzymes, along with microbial enzymatic systems, contribute to mycotoxin detoxification. Specificprobiotic strains such as Lactobacillus and Bifidobacterium transform aflatoxins, ochratoxins, andtrichothecenes into less toxic forms. Micronutrients like vitamins A, C, E, selenium, and polyphenolsmodulate detox pathways and redox balance. Prebiotics and polyunsaturated fats support microbialprofiles favoring detoxification. Synergistic interventions, such as probiotic–prebiotic systems(PPSP), show promise in enhancing host resilience. The proposed gut microbiota–nutrition–mycotoxin triad offers a novel, integrative framework for mitigating foodborne toxicity.Understanding this biochemical cross-talk opens new avenues for precision nutrition, functionalfood development, and microbiome-targeted interventions aimed at reducing mycotoxin-inducedhealth risks