Metabolic Syndrome and Assisted Reproductive Techniques

Maryam Kianpour; Mina Fazlollahi Mohammadi; Ashraf Kazami; Fatemeh Mokhtari; Sara Arti; Seyed Mehdi Ahmadi

doi:10.18502/jfrh.v17i2.12870

Maryam Kianpour Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mina Fazlollahi Mohammadi Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Ashraf Kazami Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Fatemeh Mokhtari Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Sara Arti Nursing and Midwifery Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Seyed Mehdi Ahmadi Isfahan Fertility and Infertility Center, Isfahan, Iran

DOI: https://doi.org/10.18502/jfrh.v17i2.12870

Keywords: Infertility; Metabolic Syndrome; Assisted Reproductive Technique; Body Mass Index; Iran

Abstract

Objective: Metabolic syndrome is a risk factor affecting reproductive health and pregnant outcomes. So far, the effect of this syndrome on the success rate of assisted reproduction techniques (ART) has not been investigated. The aim of this study was to investigate the relationship between metabolic syndrome and the success rate of ART in infertile women in Isfahan.

Materials and methods: A prospective cohort study performed on 147 women candidates using in-vitro fertilization/ intra cytoplasmic sperm injection (IVF/ICSI) and/or ICSI methods referred to Isfahan Infertility Center in two groups with metabolic syndrome(n=49) without metabolic syndrome(n=98), by convenience sampling methods in Isfahan, Iran in 2018. Body mass index (BMI) and waist, abdominal circumference, Serum triglyceride (TG), cholesterol and FBS were measured. If βHCG test was positive (day 15-16 after ART), transvaginal sonography (TVS) was done 15 days later. Pregnant women were followed up to the 20th week of pregnancy. To analyze, t-test, chi-square and logistic regression tests were used.

Results: The frequency of metabolic syndrome was 33.4% (n=49).The frequency of ART was not significantly different between women with and without metabolic syndrome (p=0.321). The relative frequency of pregnancy (p=0.907) and abortion (p=0.896) did not show a significant difference between the two groups. Independent t-test showed that the mean FBS, HDL, TG, systolic and diastolic BP, abdominal circumference and BMI in the studied units did not differ significantly based on the occurrence of pregnancy and abortion.

Conclusion: According to the results of this study, there was no significant difference between the indicators of metabolic syndrome and the success rate of ART in achieving, pregnancy and pregnant outcomes in the first twenty weeks of pregnancy.