Massive Splenomegaly: A Rare Presentation of Megaloblastic Anemia

Tahereh  Gholipur-Shahraki; Alireza Sadeghi; Padideh Oghab; Pegah Farrokhi; Azadeh Moghaddas

doi:10.18502/ijhoscr.v15i2.6044

Tahereh Gholipur-Shahraki Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
Alireza Sadeghi Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Padideh Oghab Department of Oncology and Hematology, Isfahan University of Medical Sciences, Isfahan, Iran
Pegah Farrokhi Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
Azadeh Moghaddas Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

DOI: https://doi.org/10.18502/ijhoscr.v15i2.6044

Keywords: Megaloblastic anemia; Splenomegaly; Vitamin B12

Abstract

Megaloblastic anemia is a common disorder with various manifestations. Of the many causes, cobalamin or folate deficiency can eventuate into megaloblastic anemia. It can lead to pancytopenia and mild to moderate splenomegaly, but massive splenomegaly rarely seen in this situation. We describe a 39-yearold woman with marked enlargement of the spleen and pancytopenia that was found to have megaloblastic anemia. The splenomegaly and blood count resolved 4 months after initiation of vitamin B12 therapy. It is important to know massive splenomegaly may occur in megaloblastic anemia, and although it is rare, bur can reversible with early treatment.