Durable Remission after Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) for Refractory Mycosis Fungoides: A Case Report

Mekni  Sabrine; Ben Hammamia  Hana; Noureddine  Litaiem; Kanoun Rimmel  Yosra; Torjemane  Lamia; Belloumi  Dorra; Ben Yaiche  Insaf; Ouerghi  Rihab; Turki  Ines; Chaabane  Anna; Ben Othman  Tarek; Ben Abdeljelil  Nour

doi:10.18502/ijhoscr.v19i2.18557

Mekni Sabrine Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Ben Hammamia Hana Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Noureddine Litaiem Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Kanoun Rimmel Yosra Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Torjemane Lamia Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Belloumi Dorra Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Ben Yaiche Insaf Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Ouerghi Rihab Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Turki Ines Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Chaabane Anna Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Ben Othman Tarek Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia
Ben Abdeljelil Nour Faculty of Medicine, University of Tunis El Manar, National Center of Stem cell Transplantation, Tunis, Tunisia

DOI: https://doi.org/10.18502/ijhoscr.v19i2.18557

Keywords: Mycosis Fungoides; Allogeneic stem cell transplantation; Refractory

Abstract

Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma (CTCL) and is characterized by a heterogeneous clinical course and variant stage involvement. Indolent disease is usually observed in its early stages. However, the treatment options for patients with advanced MF are limited and have poor outcomes. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potential curative treatment for refractory cases. Here, we describe the case of a 34-year-old man who was diagnosed with MF at an advanced stage. Eight months before allo-HSCT, the patient received six courses of polychemotherapy based on cyclophosphamide, doxorubicin, vincristine, and prednisolone, which were administered every three weeks. A partial response was obtained.

He underwent allo-HSCT after a myeloablative conditioning regimen and remained in complete remission (CR) for 26 months posttransplantation. Our findings confirm that allo-HSCT can be a curative option for refractory MF.