Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström’s Macroglobulinemia in Remission: An Unusual Report with Review

Ankit  Jitani; Mayur Babasaheb  Mundhe; Kazi Wajid  Husain; Hemant  Menghani; Maharshi  Desai; Velu  Nair

doi:10.18502/ijhoscr.v18i4.16767

Ankit Jitani Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India
Mayur Babasaheb Mundhe Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India
Kazi Wajid Husain Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India
Hemant Menghani Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India
Maharshi Desai Apollo Hospitals International Ltd, Ahmedabad, Gujarat, India
Velu Nair Apollo CBCC Cancer Care, Ahmedabad, Gujarat, India

DOI: https://doi.org/10.18502/ijhoscr.v18i4.16767

Keywords: Waldenström’s macroglobulinemia; Eosinophilic gastrointestinal disease (EGID); Eosinophilia

Abstract

Waldenström macroglobulinemia (WM) is a rare lymphoproliferative malignancy presenting with para-proteinemia. The symptoms are attributable to both lymphoproliferation and IgM flare. Gastrointestinal manifestations are not uncommon. It is an indolent disease with good response to chemoimmunotherapy but with possible persistence of asymptomatic paraproteinemia. Resurgence of gastrointestinal symptoms in a patient of WM maintaining reasonable response warrant a thorough search for alternate pathology. Herein we describe a rare case of sequential occurrence of WM with Eosinophilic Gastrointestinal Disease posing a diagnostic and therapeutic challenge.