A Study of Association of ABO and Rh Blood Group with Colorectal Cancer in Khuzestan Province, Iran

Hosein Jodat; Javad Jodat; Ali Khodadadi; Abdolhassan Talaiezadeh; Nazanin Joudaki; Ali Asadirad

doi:10.18502/ijhoscr.v17i4.13919

Hosein Jodat Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Javad Jodat Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Ali Khodadadi Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abdolhassan Talaiezadeh Cancer Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nazanin Joudaki Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Ali Asadirad Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

DOI: https://doi.org/10.18502/ijhoscr.v17i4.13919

Keywords: ABO blood-group system; Rh-Hr blood-group system; Colorectal neoplasms; Risk factors; Solid tumors

Abstract

Background: Colorectal cancer, a solid tumor with a high prevalence, contributes significantly to annual mortality rates. Various factors, including blood groups, may influence cancer risk. Multiple studies have suggested a potential connection between ABO and Rh blood groups and colorectal cancer risk. This study aims to investigate the role of ABO and Rh blood groups as risk factors in colorectal cancer patients.

Materials and Methods: We conducted a retrospective study involving 71 colorectal cancer patients diagnosed between 2018 and 2020 in Khuzestan province, Iran, with known ABO blood types. Large-scale data from 29,922 blood donors in Khuzestan served as the healthy population control. The study analyzed the distribution of ABO blood groups among the blood donors.

Results: Our findings revealed that the distribution of blood groups among colorectal cancer patients was as follows: O (31.0%), A (29.6%), B (29.6%), and AB (9.8%). However, our analysis did not establish a significant association between colorectal cancer risk and ABO antigens (P-value = 0.636) or Rh blood group (P = 0.198). Additionally, no significant differences in ABO blood types were observed concerning gender (P = 0.802), cancer type (P = 0.338), or tumor type (P = 0.207) among colorectal cancer patients.

Conclusion: This study does not support a significant correlation between ABO and Rh blood groups and the risk of colorectal cancer, nor does it find associations with cancer type or tumor type.