Whole grains and legumes consumption in association with neuromyelitis optica spectrum disorder odds

Nasim Rezaeimanesh; Shadi Ariyanfar; Mohammad Ali Sahraian; Abdorreza Naser Moghadasi; Zeinab Ghorbani; Soodeh Razegh-Jahromi

doi:10.18502/cjn.v20i3.7688

Nasim Rezaeimanesh Student Research Committee, Department of Nutrition Sciences and Food Technology, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shadi Ariyanfar Student Research Committee, Department of Nutrition Sciences and Food Technology, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Ali Sahraian Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Abdorreza Naser Moghadasi Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Zeinab Ghorbani Department of Clinical Nutrition, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Soodeh Razegh-Jahromi Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/cjn.v20i3.7688

Keywords: Neuromyelitis Optica; Whole Grains; Fabaceae; Diet

Abstract

Background: The environmental risk factors of neuromyelitis optica spectrum disorder (NMOSD) are not fully specified. Regarding the evidence on the possible protective effects of whole grains and legumes against inflammatory disorders, we examined the association between the mentioned dietary components and NMOSD.

Methods: 70 patients with NMOSD with definite diagnosis and 164 hospital-based controls were included in this case-control investigation. Data on demographic, clinical, and anthropometric characteristics were collected. Dietary habits of participants were assessed using a previously validated food frequency questionnaire (FFQ) containing 168 food items. Daily intakes of whole grains and legumes were calculated and classified in quartiles. The odds of suffering from NMOSD according to the quartiles of whole grains and legumes were measured in the form of logistic regression models.

Results: The mean amount of whole grains (115.29 vs. 44.14 g) and legumes (59.43 vs. 34.50 g) consumption was significantly higher in the control group versus the case group. There was a reverse association between whole grains or legumes and NMOSD odds