Polymorphisms of serotonin transporter gene and psychological status in patients with multiple sclerosis

Shirin Farjadian; Bahareh Fakhraei; Zahra Niknam; Mahboubeh Nasiri; Aslan Azad; Mojtaba Farjam; Alireza Nikseresht

doi:10.18502/ijnl.v17i3.366

Shirin Farjadian
Bahareh Fakhraei
Zahra Niknam
Mahboubeh Nasiri
Aslan Azad
Mojtaba Farjam
Alireza Nikseresht

DOI: https://doi.org/10.18502/ijnl.v17i3.366

Keywords: Multiple Sclerosis; Depression; Serotonin Reuptake Transporter Protein; C. Elegans; Genetic Variation

Abstract

Background: Multiple sclerosis (MS) is the most common neuroinflammatory disease in young adults. Anxiety and depression may predispose individuals to MS and flare-ups. Serotonin transmission is modified in some brain regions of patients with MS, and these changes may contribute to their psychiatric abnormalities. We studied the frequencies of common polymorphisms of the serotonin reuptake transporter (SERT) gene in patients with MS according to their psychological status.

Methods: The 5-HTTLPR, rs25531, and STin2VNTR polymorphisms of the SERT gene were genotyped by polymerase chain reaction (PCR)-based methods in 100 patients with MS and 100 healthy controls.

Results: There were no remarkable differences in SERT gene polymorphisms between patients with MS and healthy controls. Unlike the control group, 41% of the patients showed some degree of depression based on Beck Depression Inventory (BDI), but no association was observed between SERT gene polymorphisms after the patients were stratified by depression status.

Conclusion: In addition to SERT gene

polymorphisms, modulation of serotonin at the synapses may also be regulated by genetic variations in tryptophan hydroxylase type 2 and serotonin receptors. Further studies with functional brain imaging of the serotonergic system in patients with MS can provide information on the role of serotonin in this disease.