The evaluation of complete blood  count parameters in the patients  with idiopathic versus secondary  cerebral venous thrombosis

Mohammad Javad  Gholamzadeh; Etrat  Hooshmandi; Zahra  Ghahramani; Reza  Fereidooni; Alireza  Rezvani; Maryam  Vasaghi-Gharamaleki; Hossein  Molavi-Vardanjani; Sadegh  Shirian; Nima  Fadakar; Vahid Reza  Ostovan; Maryam  Poursadeghfard; Nahid  Ashjazadeh; Afshin  Borhani-Haghighi

doi:10.18502/cjn.v23i2.16838

Mohammad Javad Gholamzadeh Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Etrat Hooshmandi Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Ghahramani Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Reza Fereidooni Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
Alireza Rezvani Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Vasaghi-Gharamaleki Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Hossein Molavi-Vardanjani MD-MPH Dual Degree Program, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Sadegh Shirian Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
Nima Fadakar Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Vahid Reza Ostovan Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Poursadeghfard Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Nahid Ashjazadeh Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Afshin Borhani-Haghighi Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

DOI: https://doi.org/10.18502/cjn.v23i2.16838

Keywords: Cerebral Venous Thrombosis; Complete Blood Count; Red Blood Cell; Erythrocyte Indices

Abstract

Background: Several laboratory markers derived from a complete blood count (CBC) have been proposed as potential indicators for assessing the risk of cerebral venous thrombosis (CVT). However, limited and conflicting evidence exists regarding this association. This study aimed to evaluate the role of CBC parameters in CVT development and their link to disease characteristics.

Methods: This case-control study included patients diagnosed with CVT between March 2018 and and March 2021. All participants with CVT were registered in the organized registry system at the Neurology Research Center of Shiraz University of Medical Sciences, Shiraz, Iran (CVT registry code: 9001013381). The control group consisted of age- and sex-matched individuals without systemic diseases. CBC results from the control group and the first recorded hospital CBC of the patient group were collected.

Results: The study included 295 patients with CVT [49 with idiopathic CVT (iCVT) and 246 with secondary CVT (sCVT)] and 341 healthy individuals. Among the CVT group, 72.54% were women. Patients with CVT had higher red cell distribution width (RDW) and lower red blood cell (RBC) count, hemoglobin (Hb) levels, and hematocrit compared to the non-CVT group. In iCVT cases, male gender, RBC count, Hb levels, and hematocrit were notably higher compared to sCVT cases. Logistic regression analysis showed that female gender, smoking, and higher hematocrit values were associated with increased probability of iCVT.

Conclusion: The study suggests that certain CBC parameters may serve as potential markers for assessing CVT risk and differentiating between iCVT and sCVT cases. Validation and further research are needed to explore the underlying mechanisms.
March 2021.