UPAR Overexpression Could Be a Potential Favorable Prognostic Marker in Invasive Ductal Carcinoma of Breast

Ata Abbasi; Elnaz Mehdipour; Hengameh Mojdeganlou

doi:10.18502/acta.v60i5.9556

Ata Abbasi Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran
Elnaz Mehdipour Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Hengameh Mojdeganlou Department of Pathology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

DOI: https://doi.org/10.18502/acta.v60i5.9556

Keywords: Urokinase plasminogen activator (UPAR); Breast cancer; Histologic grade

Abstract

Breast cancer is the most common malignant tumor in women. Some factors, including histological grade, vascular invasion, and metastasis, are known prognostic factors. Many studies have been performed to find more predictive factors such as urokinase plasminogen activator system markers. Here, we tried to evaluate the relationship between Urokinase-type plasminogen activator receptor expression and other histopathologic parameters. 62 malignant breast tumors were enrolled. UPAR immunohistochemistry staining was performed on paraffin blocks. We evaluated the relationship between UPAR expression and histopathologic factors, including tumor size, tumor type, histologic grade, lymph node status, lymphovascular and perineural invasions, and hormone receptors status (ER, PR, and HER2). The patient's mean age was 46.18±10.35 years. We found a positive relationship between UPAR expression and the presence of carcinoma insitu (P=0.027). A negative relationship was observed between UPAR expression and lymph node involvement (P=0.01), the number of involved lymph nodes (P=0.027), and also intensity and percentage of UPAR positivity in the case with lymph node involvement (P=0.005 and 0.029, respectively). UPAR expression is associated with lymph node metastasis which is one of the most important predictors of prognosis in breast cancer. So, it could be used as a favorable prognostic factor in breast cancer.