Comparison of the Prophylactic Effect of Propofol, Dexamethasone and Ondansetron on Post-Operative Nausea and Vomiting in Elective Cesarean Section Under Spinal Anesthesia

Ebrahim Hassani; Nazli Karami; Asma Hassani; Leila Hassani; Veghar Ashraf

doi:10.18502/acta.v59i12.8059

Ebrahim Hassani Department of Anesthesiology, Clinical Research Development Unit, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran
Nazli Karami Department of Anesthesiology, Clinical Research Development Unit, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran
Asma Hassani Department of Anesthesiology, Seyyed-al Shohada University Hospital, Urmia University of Medical Sciences, Urmia, Iran
Leila Hassani Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
Veghar Ashraf Department of Anesthesiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

DOI: https://doi.org/10.18502/acta.v59i12.8059

Keywords: Propofol; Dexamethasone; Ondansetron; Nausea; Vomiting; Cesarean section

Abstract

Nausea, and vomiting are common complications in women undergoing cesarean section with spinal anesthesia. This study aimed to compare the propofol, dexamethasone, and ondansetron effects on nausea and vomiting. In this double-blind, randomized clinical trial study, 120 women aged 15 to 35 years candidates for cesarean section under spinal anesthesia were enrolled. Patients were randomly divided into four groups (three-drug groups and control group). Patients received 0.05 mg/kg ondansetron (group O), 0.1 mg/kg dexamethasone (group D), 0.2 mg/kg propofol (group P) and normal saline in controls (group C). Nausea and vomiting in recovery and 6 hours after surgery compared between groups. In recovery and 6 hours after surgery, both nausea and vomiting were the highest in group C while they were lowest in group O. the frequency of nausea was 11(36.7%) in both recovery and 6 hours after surgery, and the frequency of vomiting was 12(40%) and 10(33.3%) in the recovery and 6 hours after surgery respectively. Among three drug groups, nausea and vomiting were higher in group D in both the recovery room and 6 hours after surgery. The frequency of vomiting was 10 (33.3%) and 5 (16.7%) in recovery and 6 hours after surgery in group D, respectively. These differences were statistically significant between the four groups (P<0.05). The preventive effect of dexamethasone is not very useful in both periods. Therefore, it can be recommended that in the short period after surgery, propofol has a beneficial effect in preventing postoperative nausea and vomiting.