The Association of Extravasated Platelet Aggregation With Clinical Futures in Patients With Colorectal Cancer and Its Correlation With EMT Markers

Naghmeh  Ahmadiankia; Maryam  Yarmohammadi; Azam   Hadi; Behnaz  Jafari; Mozhgan   Fazli; Zahra   Shahmohammadi

doi:10.18502/acta.v58i6.4052

Naghmeh Ahmadiankia
Maryam Yarmohammadi
Azam Hadi
Behnaz Jafari
Mozhgan Fazli
Zahra Shahmohammadi

DOI: https://doi.org/10.18502/acta.v58i6.4052

Keywords: Clinical futures; Colorectal cancer; Epithelial-mesenchymal transition; Platelets

Abstract

The theory of platelet role in cancer progression was recently introduced. We investigated the association of extravasated platelets in colorectal cancer with clinicopathological features, and also the expression of epithelial-mesenchymal transition (EMT) markers. We retrospectively analyzed data from 33 patients with colorectal cancer who underwent surgery between 2013-2016. In formalin-fixed paraffin-embedded tissues, we evaluated the expression of a platelet-specific marker of CD42b and EMT markers using immunohistochemistry. The associations among the expression of the platelet‑specific marker in specimens, EMT, and clinicopathological futures were analyzed. The presence of platelets was observed in 15 out of 33 primary colorectal tumors (45%). According to multivariate analysis, CD42b expression was not correlated with clinical characteristics. Platelet-positive tumor cells did not show EMT marker expression. These data suggest that extravasated platelets may not have a central role in determining patient characteristics and clinical futures.