Effect of Glycemic Control on Right Heart Functions in Type 2 Diabetes Mellitus Patients Free of Clinical Cardiovascular Disease

Abstract

Diabetes mellitus (DM) is one of the most common endocrine disorders. 90% percent of all diabetics are diagnosed with type 2 DM. DM is closely associated with various vascular diseases, and successful glycemic control prevents micro and macrovascular complications. Although there is data about the relation between glycemic control and left ventricle function, there is hardly any data about the relation between the right ventricular function. We analyzed the relationship between glycemic control and right ventricle function in type 2 DM patients free of clinical cardiovascular diseases (CVD). Patients were selected from the cardiology outpatient clinic. 53 patients formed the DM group; 51 patients formed the control group. All patients' demographic data were recorded. Biochemical tests and echocardiographic examinations were performed. RA and RV diameters were significantly higher in DM group (3.36±0.32 vs 3.13±0.34, P=0.015; 2.80±0.32 vs 2.56±0.22 P=0.005 respectively). Myocardial velocity during isovolumetric contraction (RV/IVV) and myocardial acceleration during Isovolumetric contraction (RV/IVA) were significantly lower in the DM group (14.4±3.17 vs 16.04±4.13 P=0,019; 3.25±0.75 vs 3.95±1,25 P=0.015). There was an intermediate negative correlation between RV/IVV and HBA1C (r=-0.406; P=0.036). HBA1C level was an independent risk factor for RV IVV (β=-0.406; P=0.036). It is shown that RA, RV diameter were significantly higher; RV/IVV and RV/IVA were significantly lower in diabetes mellitus patients free of CVD. Furthermore, there was a significant negative correlation between RV/IVV and HBA1C levels. HBA1C level was an independent risk factor for RV/IVV.