Effect of Carbogen to Chemoradiation in Volume of Rectal Cancer

Christina Hari Nawangsih; Soehartati Gondhowiardjo; Sofia Mubarika Haryana; Soeharyo Hadisaputro; Catharina Suhart; Edi Dharmana; Hermina Sukmaningtyas; Fifin Luthfia Rahmi; Ignatius Riwanto

doi:10.18502/acta.v58i1.3702

Christina Hari Nawangsih
Soehartati Gondhowiardjo
Sofia Mubarika Haryana
Soeharyo Hadisaputro
Catharina Suhart
Edi Dharmana
Hermina Sukmaningtyas
Fifin Luthfia Rahmi
Ignatius Riwanto

DOI: https://doi.org/10.18502/acta.v58i1.3702

Keywords: Rectal cancer; Carbogen; Chemoradiation; Volume

Abstract

The outcome of inoperable rectal cancer treatment by chemotherapy, radiotherapy, and targeted therapy are still unfavorable. Carbogen is a combination of 98% oxygen and 2% carbon dioxide proven effective as chemoradiosensitizer. The aim of this study is to know the effect of concurrent carbogen and chemoradiotherapy in locally advanced rectal cancer by measuring the shrinkage of the tumor volume. The design of this study was randomized true experimental 2 groups pre and post-test-controlled design. Samples were patients with locally advanced rectal cancer. MRI of the pelvis before and 4-8 weeks after the chemoradiation were examined. A total of 28 subjects were randomized to 14 patients who received concurrent chemoradiation with carbogen (treatment group) and 14 patients chemoradiation (control) The tumor shrinkage in the treatment group (13.08 to 6.08 cm3 ) was significantly higher compared to the control group (18.00 to 12.83 cm3 ). Supplementation of carbogen to standard treatment chemoradiation for locally advanced rectal cancer significantly shrinkage the tumor volume.