Effects of Dietary Flaxseed and Atorvastatin on Blood Hematology and Renal Health Metrics in Rats Fed High-Fat Diet

Abstract

Flaxseed is rich in omega-3 fatty acids and dietary fiber, both of which contribute to reduced inflammation and oxidative stress in the kidneys. Moreover, atorvastatin appears to enhance the activity of important antioxidant enzymes, potentially reducing the risk of chronic kidney disease and hematological disorders. Eighty male Wistar rats were divided randomly into ten groups: 1) ND (normal diet) 2) HFD (high-fat diet), 3) HFD+ ATO 10, 4) HFD+ ATO 20, 5) HFD+ FO (flaxseed oil), 6) HFD+ F (flaxseed), 7) HFD + ATO 10 + FO, 8) HFD + ATO 20 + FO, 9) HFD + ATO 10 + F, and 10) HFD + ATO 10 + F. Atorvastatin 10 and 20 mg/kg, FO 40 mg/kg, and flaxseed 40 g/kg were administrated for 8 weeks. After 23 weeks, serum level of kidney markers and CBC parameters were evaluated. ATO 20 led to reduce WBC, RBC, and HCT. Furthermore, ATO 20 + FO decreased WBC and ATO 20 + F reduced PLT, RBC and HCT. Administration of ATO 10 cause to increase creatinine (Cr) levels but other interventions had better effect on Cr, however these effects weren’t notable. There weren’t significant differences in Hb, MCV, MCH, MCHC, and urea between groups. F/FO therapies with ATO seems to have synergistic effects to improved dyslipidemia-associated kidney injuries and hematological indices. Although high dose of ATO can be more efficient than low dose.