Association Between Serum Uric Acid to HDL-Cholesterol Ratio as a Novel Indicator of Inflammation and Ischemic Changes on Electrocardiogram: The MASHAD Cohort Study

Rana Kolahi  Ahari; Toktam  Sahranavard; Mohsen  Moohebati; Hossein  Hatamzadeh; Maryam  Mohammadi-Bajgiran; Sahar  Ahmadi; Alireza  Heidari-Bakavoli; Sara Saffar  Soflaei; Majid Ghayour  Mobarhan

doi:10.18502/acta.v64i1.21034

Rana Kolahi Ahari Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Toktam Sahranavard Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mohsen Moohebati Heart and Vascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Hossein Hatamzadeh Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Mohammadi-Bajgiran International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad,
Sahar Ahmadi International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Alireza Heidari-Bakavoli Vascular and Endovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Sara Saffar Soflaei International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Majid Ghayour Mobarhan International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: https://doi.org/10.18502/acta.v64i1.21034

Keywords: Uric acid to HDL-cholesterol ratio; Electrocardiogram; Ischemic ECG abnormalities

Abstract

This study aimed to explore the association between serum uric acid to high-density lipoprotein cholesterol ratio (UHR) and minor and major ischemic electrocardiogram (ECG) changes. The data from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study comprised 9035 participants aged 35 to 65 years. A 12-lead resting ECG was recorded at baseline for participants. ECG abnormalities were defined according to the Minnesota coding system and classified into three groups: none, minor, and major ischemic changes. Minor and Major ischemic changes were observed in 6.2% and 14.1% of participants, respectively. Participants in the major ischemic group had higher UHR levels compared to those without ischemic changes on their ECG (odds ratio (OR)=0.023, 95% confidence interval (95% CI)=1.011-1.035, P<0.001). UHR remained correlated with major ischemic ECG changes after adjustment for either age (OR=0.019, 95% CI=1.007-1.031, P=0.001) or various cardiovascular risk factors (OR=0.018, 95% CI=1.006-1.030, P=0.004). UHR was not significantly associated with minor ischemic changes. This research showed, for the first time, that UHR was significantly associated with major ischemic ECG changes. Indeed, the UHR provides additional information for risk stratification of subjects with myocardial ischemia.