Unveiling Parry-Romberg Syndrome With Native Demyelinating Etiology as the Underlying Cause

Kaveh Bahrami; Mohammad Ali Nahayati; Mohammad Shriati; Ayoub Tavakolian; Hussein Sharare

doi:10.18502/acta.v61i12.16374

Kaveh Bahrami Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Ali Nahayati Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Shriati Department of Stem Cell and Regenerative Medicine, Academic Centre for Education, Culture and Research (ACECR), Khorasan Razavi, Mashhad, Iran
Ayoub Tavakolian Department of Emergency Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Hussein Sharare Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

DOI: https://doi.org/10.18502/acta.v61i12.16374

Keywords: Parry-romberg syndrome; Hemifacial atrophy; Multiple sclerosis; Radiologically isolated syndrome

Abstract

Parry-Romberg Syndrome (PRS) is an atypical condition characterized by hemiatrophy of the face. Despite its rarity, the precise pathophysiological processes underlying its etiology remain elusive. While previous reports have hinted at the potential involvement of autoimmune factors, our case report aims to explore a novel perspective. Specifically, we pose the question of whether multiple sclerosis (MS) could be a plausible causative factor for PRS. Additionally, we investigate the potential association between Radiologically Isolated Syndrome (RIS) and the development of Parry-Romberg Syndrome.