Association of Maternal Diabetes and ADHD in Offspring: A Systematic Review and Meta-Analysis

Batool Okhovat Isfahani; Farzad Khodamoradi

doi:10.18502/acta.v61i6.13829

Batool Okhovat Isfahani West Health Center of Tehran, Iran University of Medical Sciences, Tehran, Iran
Farzad Khodamoradi Department of Social Medicine, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

DOI: https://doi.org/10.18502/acta.v61i6.13829

Keywords: Attention deficit disorder with hyperactivity; Diabetes mellitus; Systematic review

Abstract

A systematic review and meta-analysis was conducted to determine the association between exposure to maternal diabetes and ADHD in the offspring. Major electronic databases, including Web of Science, PubMed, Scopus, Embase, and Proquest, were searched from inception until December 2018. The New Castle-Ottawa scale was used to assess the quality of the included studies. A fixed effects model was applied for analysis. Seven studies including a total of 5,658,871 individuals were retained. A significant association was found between maternal diabetes and ADHD [OR=1.23, 95% CI: 1.117, 1.345]. There was a significant heterogeneity (I^2=77.7, P<0.0001), while Egger’s and Begg’s test were not significant. This study showed a significant relationship between maternal diabetes and ADHD; however, more well-designed studies are needed to confirm the results.