Laryngeal Cancer in Iranian Women

Payman Dabirmoghaddam; Jaleh Yousefi; Ebrahim Karimi; Kayvan  Aghazadeh; Mahdi Moteshaker Arani

doi:10.18502/acta.v61i1.12120

Payman Dabirmoghaddam Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Jaleh Yousefi Department of Otorhinolaryngology, New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Ebrahim Karimi Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Kayvan Aghazadeh Department of Otorhinolaryngology, Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Mahdi Moteshaker Arani Department of Otorhinolaryngology, New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/acta.v61i1.12120

Keywords: Cancer; Larynx; Neoplasm; Survival; Women

Abstract

Laryngeal cancer is the most common malignant neoplasm in respiratory tract after lung cancer. The incidence is very different and male to female ratio has been decreased in previous decades. Different characteristics of laryngeal cancer in men and women have been described based on previous studies, so we decided to study its characteristics in Iranian women. This study's design is cross-sectional retrospective from 2010 to 2019 in Amir-Alam Hospital, Tehran University of Medicine. All patients with laryngeal cancer admitted to this hospital, were included. Females` records were studied exclusively. Among 1456 patients included in this study, 1391 were male and 65 were female(M/F=21.4:1). The mean age of males was 60.6 years and for females was 56.6. From 65 females, 60 were Squamous cell carcinoma and 5 were Sarcoma. Findings of 60 female SCC patients: The main risk factors were cigarette smoking and opium abuse. The subsite of tumor was supraglottic in 40%, glottis in 31% and transglottic in 29%. Treatment options were surgical (55%) and non-surgical (45%). Survival rates for one, two and five years were 84.3%, 67.4% and 44% respectively. Two-year survival of surgically treated patients is significantly better than non-surgically treated patients (P=0.048). The mean age of females was less than males. Two-year survival rate was better in surgically treated patients. The five-year survival of female patients was 44% and there is an emerging need for survival studies of male patients for comparison.