Serum Hepcidin and Ferritin Have Not Correlation With Inflammatory Markers in Kidney Transplant Patients

Nayyereh Sadat  Mortazavi Khorasgani; Ali Momeni; Soleiman Kheiri; Rohollah Masumi; Saeed Mardani; Fateme Salehi Choliche; Maryam Saeedi; Farzad Rashidi; Sepideh  Shabani Broujeni

doi:10.18502/acta.v60i6.10039

Nayyereh Sadat Mortazavi Khorasgani School of Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
Ali Momeni Department of Internal Medicine, School of Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
Soleiman Kheiri Social Health Departments Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
Rohollah Masumi Department of Internal Medicine, School of Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
Saeed Mardani Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Fateme Salehi Choliche School of Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
Maryam Saeedi School of Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran
Farzad Rashidi Department of Immunology, School of Medicine, University Complutense, Madrid, Spain
Sepideh Shabani Broujeni School of Medical Sciences, Shahrekord University of Medical Sciences, Shahrekord, Iran

DOI: https://doi.org/10.18502/acta.v60i6.10039

Keywords: Inflammatory factor; Kidney transplant; Hepcidin; Ferritin

Abstract

In renal transplant patients, increased ferritin is associated with an increased risk of cardiovascular disease, transplant rejection, and mortality. Serum ferritin elevates in renal transplant patients due to blood product transfusion, inflammation, and malignancies. Hepcidin is also a peptide hormone produced in the liver in response to anemia, hypoxia, or inflammation. The aim of this study was to investigate the relationship between ferritin, hepcidin, iron, TIBC, and serum inflammatory markers in renal transplant patients. The cross-sectional descriptive-analytical study was conducted on 60 renal transplant patients referred to Hazrat-Rasool and Imam-Ali clinics and Al-Mahdi Laboratory of Shahrekord selected by convenience sampling method. Serum ferritin, hepcidin, iron, TIBC, and inflammatory markers levels were determined by standard kits by ELISA. Data were analyzed by SPSS software. Serum iron had a significant negative correlation with erythrocyte sedimentation rate (ESR) (r= -0.418, P=0.001) and a negative correlation with C reactive protein (CRP) (r= - 0.243, P=0.061). TIBC had a significantly negative association with ferritin (r= - 0.27, P=0.037). Ferritin, hepcidin, and TIBC were not significantly correlated with inflammatory factors. The results of the study showed no significant relationship between ferritin, hepcidin, and TIBC with inflammatory factors in renal transplant patients.