Evaluation of the Relationship between rs17561 and rs1143634 Genetic Polymorphisms and the Risk of Chronic Periodontitis

Jaber Yaghini; Amir  Farmohammadi; Mohammad  Karimian; Mina Jamshidi

doi:10.18502/ijds.v18i4.12099

Jaber Yaghini Professor, Department of Periodontology, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Amir Farmohammadi Dentist, Department of Periodontology, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Karimian Assistant Professor, Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
Mina Jamshidi Post Graduate Student, Dental Students Research Committee, Department of Periodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

DOI: https://doi.org/10.18502/ijds.v18i4.12099

Keywords: Chronic periodontitis; Interleukin 1; Genetic polymorphism

Abstract

Introduction: Genetic diversity in cytokines such as interleukin α1 and interleukin 1β is involved in altering the immune response in inflammatory diseases such as chronic periodontitis and changes the risk of this disease. The aim of this study was to investigate the association of genetic polymorphisms 4845G> T interleukin 1α and 3954C> T interleukin 1β with the risk of chronic periodontitis.
Materials & Methods: Participants including 133 healthy individuals and 133 individuals with chronic periodontitis referred to Isfahan Dental School, were included in the study. The genotype of blood samples at the site of the above polymorphism was determined by PCR-RFLP method. The relationship between the studied polymorphisms and chronic periodontitis was calculated by logistic regression test. Statistical analyzes were performed by SPSS software. The p value level < 0.05 was statistically significant.
Results: Data analysis showed a significant relationship between CT and TT genotypes and T allele of polymorphism 3954C> T interleukin 1β and increased risk of chronic periodontitis and no significant relationship between polymorphism 4845G> T of interleukin 1α and the risk of Showed chronic periodontitis.
Conclusion: Based on the above data, T> 3954C polymorphism is a risk factor for chronic periodontitis and serves as a potential biomarker for screening people prone to this disease.