Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

Monir Moradzadeh Khiavi; Abbas Karimi; Hassan Mirmohammad Sadeghi; Samira Derakhshan; Seyed Mobin Tafreshi; Samar Jalali

doi:10.18502/fid.v18i44.8340

Monir Moradzadeh Khiavi Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Abbas Karimi Department of Oral and Maxillofacial Surgery, School of Dentistry and Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Hassan Mirmohammad Sadeghi Department of Oral & Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Samira Derakhshan Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Seyed Mobin Tafreshi Dental Student, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran
Samar Jalali Dental Student, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/fid.v18i44.8340

Keywords: Granuloma, Giant Cell; Fibroma; Odontogenic Tumors

Abstract

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.