Intraoral Bone Regeneration Using Stem Cells - What a Clinician Needs to Know: Based on a 15-Year MEDLINE Search

Vanshika  Jain; Deborah   Sybil; Shubhangi   Premchandani; Meenakshi  Krishna; Sanjay  Singh

doi:10.18502/fid.v18i40.7774

Vanshika Jain Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, New Delhi, India
Deborah Sybil Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
Shubhangi Premchandani Intern, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
Meenakshi Krishna BDS 3rd year, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India
Sanjay Singh Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India

DOI: https://doi.org/10.18502/fid.v18i40.7774

Keywords: Adult Stem Cells; Mesenchymal Stem Cells; Review; Bone Regeneration; Cell- and Tissue-Based Therapy

Abstract

The choice of an appropriate autogenous source of stem cells has not been adequately addressed especially for intraoral bone regeneration. The current review aims to assess the clinical success of various human stem cells in oral bone regeneration. Articles studying the potential of various stem cells utilized for reconstruction of intraoral bone defects in humans were included in this review. Relevant articles were electronically searched in MEDLINE-PubMed database using keywords with different combinations. Only the articles published in English between 2006 and 2020 were included in this review. It was concluded that intra and extraoral stem cells can be successfully used for bone regeneration of various jaw defects. Depending on the origin, quantity, and quality, each cell type has its own advantages and disadvantages. Also, it brings to the fore the need for more clinical studies to validate and adopt the use of stem cells in regular clinical practice.