Potential Implications of Organoids in Dental Research

Abstract

Organoids are among the most significant advancements in the past few years that have revolutionized the medical and dental research. These experimental organs have been used to study the developmental processes, pathophysiology, genetic mutations, and drug effects. The organoid technology is an important adjunct to two-dimensional culture methods and animal models. Stem cells are grown in specific environments to develop the organoids, thus, simulating the complexity of the in vivo environment. Oral organoids also recapitulate the architecture and functions of in vivo organs and tissues in the oral and maxillofacial region. Organoids are a promising tool to manipulate human dental stem cell biology for comprehending tooth-regenerative approaches, infectious diseases, genetic anomalies, oral cancer, and drug discovery.