A Randomized Controlled Clinical Trial Comparing Clinical and Radiographic Success Rates of MTA and rhBMP2 in Pulpotomy of Primary Teeth

Nosrat  Nourbakhsh; Sanaz  Ziaei; Hesam  Panahi; Nahad  Sedaghat; Amirhossein  Behnia

doi:10.18502/fid.v21i12.15224

Nosrat Nourbakhsh Department of Pediatric Dentistry, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Sanaz Ziaei Department of Pediatric Dentistry, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Hesam Panahi Department of Surgery, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Nahad Sedaghat Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Amirhossein Behnia Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord, Iran

DOI: https://doi.org/10.18502/fid.v21i12.15224

Keywords: Pulpotomy; Tooth, Deciduous; Bone Morphogenetic Proteins; Mineral Trioxide Aggregate

Abstract

Objectives: In an ideal pulpotomy, the radicular pulp remains vital, healthy, and fully encased within an odontoblastic layer. Mineral trioxide aggregate (MTA) and bone morphogenetic proteins (BMPs) have been suggested to facilitate this outcome. We aimed to compare the clinical and radiographic failure and success rates of MTA and rhBMP2 as pulpotomy medicaments.

Materials and Methods: Sixty-eight teeth from 3–6-year-old children were randomly assigned to two groups using a split-mouth design. Cervical pulpotomy was performed using MTA in one group and rhBMP2 in the other. Subsequently, the teeth were restored with stainless-steel crowns. Clinical and radiographic assessments were performed at 3, 6, 9, and 12-month follow-up intervals to evaluate success and failure rates. Data were analyzed using Chi-square test and Kaplan-Meier survival analysis (P<0.05)

Results: At six and nine months, one tooth in the BMP2 group and one tooth in the MTA group showed internal resorption, respectively. After 12 months, one tooth in the BMP2 group exhibited PDL widening. The radiographic success rate was 100% for the MTA- and 97.1% for the BMP2-group at six months, 96.7% for both groups at nine months, and 96.7% and 93.3%, respectively, at 12 months. No clinical failure criteria were observed in any of the teeth. Survival analysis revealed no significant difference between the two groups.

Conclusion: The study reveals comparable outcomes between rhBMP2 and MTA, suggesting rhBMP2 as a viable alternative for pulpotomy in primary teeth. With minimal incidences of complications and no significant differences noted, rhBMP2 demonstrates potential for clinical use.