Relapse of Sulfasalazine-induced DRESS Syndrome Following the Administration of Contrast Media: A Case Report

Niayesh Mohebbi; Hamidreza  Taghvaye Masoumi; Malihe  Khosravi Khezri; Mona Talaschian

doi:10.18502/crcp.v6i3.7121

Niayesh Mohebbi Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Hamidreza Taghvaye Masoumi Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.
Malihe Khosravi Khezri Department of Clinical Pharmacy, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
Mona Talaschian Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

DOI: https://doi.org/10.18502/crcp.v6i3.7121

Keywords: Contrast media; Drug reaction with eosinophilia and systemic symptoms; Hypersensitivity reactions; Sulfasalazine

Abstract

Sulfasalazine, a non-antibiotic sulfonamide, is associated with severe hypersensitivity reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome. We report a case of sulfasalazine-induced DRESS syndrome that relapsed following the administration of visipaque® (iodixanol). Macular rashes, pruritus, and an acute exacerbation of dyspnea were immediately observed after the administration of contrast media. It seems that patients suffering from DRESS syndrome are sensitive to the administration of other new medications with a high possibility of hypersensitive reactions. It can be concluded that iodinated contrast media should be used cautiously in patients with DRESS syndrome.