Extensive Intracranial Calcification in A Case of Hypoparathyroidism Which Presented With Generalized Tonic-clonic Seizure: A Case Report

Maryam Karimi Fard; Mehdi Kafi

doi:10.18502/crcp.v6i2.6684

Maryam Karimi Fard Non-communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mehdi Kafi Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

DOI: https://doi.org/10.18502/crcp.v6i2.6684

Keywords: Hypoparathyroidism; Intracranial calcification; Generalized tonicclonic seizure

Abstract

Hypoparathyroidism is an endocrine disorder that can be congenital or acquired. Generally, hypoparathyroidism is characterized by hypocalcemia, hyperphosphatemia, and low or abnormal levels of Parathyroid Hormone (PTH). It can be asymptomatic or symptomatic. The symptoms include seizures, paresthesia, depression, psychosis, extrapyramidal manifestations, and increased intracranial pressure. In this case study, we reported a 40-yearold male patient who was admitted to the emergency department with generalized tonicclonic movements and urine incontinency. Laboratory investigations revealed hypocalcemia, hyperphosphatemia, and low parathyroid hormone levels and in paraclinical studies, including Electroencephalography (EEG) and brain CT-scan, despite normal EEG, extensive intracranial calcification involving the basal ganglia, thalamus, white matter of the cerebral hemispheres, and subcortical area of the frontal and parietal lobes were observed on CT-scan.