Multiple Primary Metachronous Malignancies, Namely Kidney, Colon, Uterus, and Breast Cancer: A Case Report

Arian Karimi  Rouzbahani; Yahya Baharvand  Irannia; Shahram Ahmadi  Somaghian; Golnaz  Mahmoudvand; Omid-Ali  Adeli; Reza  Yusofvand

doi:10.18502/crcp.v10i5.21391

Arian Karimi Rouzbahani Western Health, Department of Urology, Melbourne, Australia.
Yahya Baharvand Irannia Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Shahram Ahmadi Somaghian Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
Golnaz Mahmoudvand USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran
Omid-Ali Adeli Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran
Reza Yusofvand Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

DOI: https://doi.org/10.18502/crcp.v10i5.21391

Keywords: Breast neoplasms; Endometrial stromal sarcoma; Papillary renal cell carcinoma; Quadruple primary neoplasms; Multiple primary malignancies (MPMs)

Abstract

The incidence of multiple primary malignancies (MPMs) has risen in clinical practice; however, cases involving three or more primary cancers remain rare. A 56-year-old postmenopausal female with a significant familial cancer history developed four primary malignancies: papillary renal cell carcinoma, endometrial stromal sarcoma, colon adenocarcinoma, and invasive ductal carcinoma of the breast. The patient passed away after one year of receiving palliative treatment for her metastatic breast cancer. This study reviews 33 cases of MPMs, primarily involving breast, colon, and uterine cancers, mostly in women over 60. Genetic predisposition plays a significant role, with 35.5% having hereditary cancer syndromes. This report emphasizes the importance of considering new masses in cancer patients as potential new malignancies. Early detection using fluorodeoxyglucose positron emission tomography (FDG-PET), implementing genetic testing, and timely cancer screenings in high-risk families significantly improve patient outcomes and management