Burkitt´s Lymphoma with Prior Varicella Infection Presenting with Guillain–Barré Syndrome: A Case Report

Zahra  Heydari; Mohammad kaji  Yazdi

doi:10.18502/crcp.v10i3.20311

Zahra Heydari Pediatric Hematology and Oncology Department, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mohammad kaji Yazdi Pediatric Hematology and Oncology Department, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.18502/crcp.v10i3.20311

Keywords: Burkitt’s lymphoma (BL); Non-hodgkin lymphoma (NHL); Guillain–barré syndrome; Varicella infection

Abstract

Burkitt’s lymphoma (BL) emerges as the most prevalent subtype of non-Hodgkin lymphoma (NHL) in pediatric populations. Several studies have demonstrated a connection between certain viral infections and Burkitt’s lymphoma, suggesting a potential correlation between these factors. Although BL typically presents with lymph node involvement, neurological manifestations are quite rare. In this report, we detail the case of a 13-year-old male patient who initially presented with a varicella zoster infection, accompanied by neurological symptoms consistent with Guillain-Barré syndrome (GBS), and subsequently developed a substantial submandibular mass. Diagnostic imaging, along with biopsy, confirmed a diagnosis of high-grade B-cell lymphoma consistent with BL.